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A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin Sign In to gain access to subscriptions and/or My Tools. Rosuvastatin is a new HMG-CoA reductase inhibitor with unique pharmacologic and pharmacokinetic properties. It has additional HMG-CoA reductase enzyme-binding interactions that cause tighter binding, has substantial active transport into hepatocytes, and has the lowest IC50 for sterol synthesis in hepatocytes. Rosuvastatin 10 mg and 80 mg dosages have superior low-density lipoprotein (LDL) cholesterol-lowering efficacy as compared to atorvastatin 10 mg and 80 mg. Rosuvastatin 10 mghas also been shown to have superior LDL reductions to 20 mg of both simvastatin and pravastatin. This agent can raise high-density lipoprotein (HDL) 8% to 12% and lower triglycerides by 10% to 35%. Rosuvastatin is a hydrophilic agent with poor penetration in extrahepatic tissue such as human umbilical vein endothelial cells and fibroblasts. It also has a low potential for cytochrome P450 drug interactions and can be dosed in the morning or night. In conclusion, rosuvastatin is an agent with molecular alterations that provide it with unique pharmacologic and phannacokinetic effects. As such, it is a novel and unique HMG-CoA reductase inhibitor for the treatment of hyperlipidemia. Rosuvastatin | Medifast Diet Reviews It is Sunday morning and I overslept and missed church. My dang cough is still keeping me awake at night but is getting less intrusive. I will be very happy with my sleep habits return to normal. I wonder how negatively it is affecting my weight loss on Medifast? I m still not supposed to be exercising and to be honest I don t feel much like doing physical activity with my cold and lack so sleep. I hope in another week I will be at full strength and ready to start working out. I am still taking walks with my dog Toby, but that is about it for activity. So my fast weight loss is even more surprising to me, if not my health coach. His prediction of 2-5 lbs per week is actually understated, as I dropped more weight this weekend. Tomorrow I will be able to post my full 2 week weight loss on the Medifast Diet plan. Reviews and User Ratings: Effectiveness, Ease of Use, and SatisfactionYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Rosuvastatin: A Review of its Use in the Prevention of Cardi... : American Journal of Cardiovascular Drugs Adis may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy.
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